Emergence of a non vaccine-cognate enterovirus A71 genotype C1 in mainland China.
J Infect
; 82(3): 407-413, 2021 03.
Article
in En
| MEDLINE
| ID: mdl-33373653
ABSTRACT
BACKGROUND:
EV-A71 is a common causative agent of hand foot and mouth disease. In mainland China, EV-A71 subgenotype C4 has been the sole circulating genotype since 2008, and was used in the production of multiple licensed vaccines. Here, we report the first detection EV-A71 C1 strains in China.METHODS:
Full genomic sequence were obtained. The origin of the EV-A71 C1 strains were tracked down by Bayesian inferences. Recombination was analyzed using Simplot program. And the antigenicity were tested using the microneutralization test.RESULTS:
The C1-GD2019 shared high identity with the C1-like lineage recently identified in Europe and was introduced into Guangdong in 2018-2019. Close genetic relatedness between the C1-GD2019 and Europe C1-like strains were observed except for the 3D-3'UTR region. The late showed high similarity with CVA genomes. Antigenic variance was found. The C1-GD2019 could not be effectively neutralized by EV-A71 C4a neutralizing antibody positive samples.CONCLUSION:
This is the first report of EV-A71 subgenotype C1 isolated in China. It is a recombinant strain originating from C1-like strains recently identified in Europe and CVA strains. The different antigenicity between the C1 strains and C4a vaccine strains highlighted the importance on closely monitoring the EV-A71 C1 strains in China.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines
/
Enterovirus
/
Enterovirus A, Human
/
Enterovirus Infections
/
Hand, Foot and Mouth Disease
Limits:
Humans
Country/Region as subject:
Asia
/
Europa
Language:
En
Journal:
J Infect
Year:
2021
Document type:
Article
Affiliation country: